Background. Surgery for primary hyperparathyroidism demands skill and
experience. The monetary and personal costs of unsuccessful surgery ar
e investigated here. Method. We reviewed 47 consecutive patients opera
ted on by one surgeon during a period of 16 months, including their cl
inical data and medical costs of their treatment. Results. All 39 pati
ents without previous operation were normocalcemic after operation, wi
th no recurrent nerve injury mor hypoparathyroidism. Of the eight had
undergone previous operation elsewhere, seven had abnormal glands that
should have been resected at the initial operation, and hypoparathyro
idism developed in two patients. Total costs or reoperative parathyroi
d surgery were more than twice the cost of an initial operation (media
n, $8383 versus $3948, p < 0.001) because of the cost of radiologic st
udies (median, $3378 versus $43, p < 0.001). Conclusions. (1) An exper
ienced parathyroid surgeon can consistently cure hyperparathyroidism a
t the initial operation. (2) The majority of patients referred for hyp
erparathyroidism not cured by previous operation have glands in usual
anatomic locations. (3) The cost of the patient of an inadequate initi
al operation includes the physical effects of remaining hyperparathyro
id, additional time off work, potentially invasive localization testin
g, reoperative surgery with increased risk of complications, and subst
antial expense. Initial parathyroid surgery should be performed by sur
geons experienced and proficient in its practice.