FEEDING EXPERIMENTS WITH AFLATOXIN AND PO LYVINYL-POLYPYRROLIDON DERIVATIVE (ANTITOX-PLUS) IN CHICKENS

In the experiment, 125 chickens were divided into five groups (I to V) . It was investigated that the ''Antitox Plus'' preparation, containin g 0.2% of polyvinyl-polypyrrolidon, how diminishes the harmful effect of experimental aflatoxicosis induced by different amounts of toxin (4 00 mu g/feed kg = group IV, as well as 1000 mu g/feed kg = group V, Ta ble 1). Body-mass gain was studied and changes in the mass of immune o rgans (busa of Fabricius, spleen) were investigated together with the pathological changes developed in the liver. The results showed that t he lack of body-mass gain was less significant in chickens consuming s imultaneously aflatoxin and Antitox Plus than in chickens without cons uming Antitox Plus (Table 2). Similar tendencies were observed in case of feed conversion (Table 3). Mass of immune organs in chickens consu ming aflatoxin was less than that of controls. Antitox Plus compensate d this backwardness, thus the mass of spleen in chickens consuming 100 0 mu g/feed kg aflatoxin was 3.73 g, on an average, while that of chic kens supplied also with Antitox Plus was 5.23 g (Table 4). Development of pathological changes in the liver caused by aflatoxicosis (patholo gical fatty degeneration, bile capillary proliferation and inflammatio n) was significantly diminished by the application of Antitox Plus (Ta ble 5).