ANANDAMIDE (ENDOGEN CANNABINOID) AFFECTS ANTERIOR-PITUITARY HORMONE-SECRETION IN ADULT MALE-RAT

Authors
WENGER T FRAGAKIS G PROBONAS K TOTH BE YIANNAKAKIS N
Citation
T. Wenger et al., ANANDAMIDE (ENDOGEN CANNABINOID) AFFECTS ANTERIOR-PITUITARY HORMONE-SECRETION IN ADULT MALE-RAT, Neuro endocrinology letters, 16(5-6), 1994, pp. 297-303
Citations number
20
Categorie Soggetti
Endocrynology & Metabolism",Neurosciences
Journal title
Neuro endocrinology letters → ACNP
ISSN journal
0172780X
Volume
16
Issue
5-6
Year of publication
1994
Pages
297 - 303
Database
ISI
SICI code
0172-780X(1994)16:5-6<297:A(CAAH>2.0.ZU;2-Y
Abstract
The recent identification and purification of anandamide (arachidonyl ethanol-amide) (ANA), the putative endogenous ligand for the cannabino id receptor provided us the chance to investigate its effects on pitui tary hormone secretion. We compared the effects of Delta(9)-tetrahydro cannabinol (THC), the main psychoactive component of the marihuana wit h ANA after chronic i.p. administration in adult male rats. Both drugs altered serum levels of luteinizing hormone, follicle stimulating hor mone, prolactin and growth hormone. Their effects seemed to be mainly inhibitory.