METAPLASTIC CARCINOMA OF THE BREAST IN A RENAL-TRANSPLANT RECIPIENT -INITIAL DIAGNOSIS BY FINE-NEEDLE ASPIRATION CYTOLOGY AND IMMUNOCYTOCHEMISTRY

Citation
Dk. Das et al., METAPLASTIC CARCINOMA OF THE BREAST IN A RENAL-TRANSPLANT RECIPIENT -INITIAL DIAGNOSIS BY FINE-NEEDLE ASPIRATION CYTOLOGY AND IMMUNOCYTOCHEMISTRY, Acta cytologica, 38(6), 1994, pp. 917-922
Citations number
20
Categorie Soggetti
Cell Biology
Journal title
ISSN journal
00015547
Volume
38
Issue
6
Year of publication
1994
Pages
917 - 922
Database
ISI
SICI code
0001-5547(1994)38:6<917:MCOTBI>2.0.ZU;2-V
Abstract
A 46-year-old woman presented with a mass in the left breast and left axillary lymphadenopathy. Five years earlier she had received a renal transplant from an unrelated donor because of end-stage renal failure secondary to adult polycystic kidney disease. She suns on immunosuppre ssion therapy in the form of cyclosporine, azathioprine and prednisolo ne. Fine needle aspiration cytology of the breast mass showed a metapl astic (sarcomatoid) carcinoma, whereas the axillary lymph node aspirat e suggested carcinosarcoma; Immunocytochemical studies revealed dense positivity for vimentin in the sarcomatous component and positivity fo r epithelial membrane antigen in the epithelial component. Rare cells were positive for cytokeratin. The cytodiagnosis was confirmed by exci sion biopsy of axillary lymph nodes. The-patient died on the fourth po stoperative day following left mastectomy and axillary clearance, The histopathology report of the breast tumor showed sarcomatoid carcinoma .