TOLERANCE FOR OPIATE ANALGESIA - COMPLEX EFFECT OF ANTAGONISTS OF RECEPTORS FOR EXCITATORY AMINO-ACIDS

Authors
BESPALOV AY ZVARTAU EE DUMPIS MA PIOTROVSKII LB
Citation
Ay. Bespalov et al., TOLERANCE FOR OPIATE ANALGESIA - COMPLEX EFFECT OF ANTAGONISTS OF RECEPTORS FOR EXCITATORY AMINO-ACIDS, Bulletin of experimental biology and medicine, 117(5), 1994, pp. 491-493
Citations number
15
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
5
Year of publication
1994
Pages
491 - 493
Database
ISI
SICI code
0007-4888(1994)117:5<491:TFOA-C>2.0.ZU;2-5
Abstract
The effect of excitatory amino acid receptor antagonists on the develo pment of the conditioned reflex component of the tolerance for morphin e analgesia is studied. It is demonstrated that the antagonists of NMD A and nonNMDA receptors reduce the development of associated component of the tolerance, while the magnitude of the nonassociative component changes after co-administration of morphine with NMDA receptor antago nists.