IMMUNOLOGICAL RESPONSES DURING THE ORGANISMS ADAPTATION TO A DOSED THERMAL FACTOR

Overheating of mice over the course of 10 and 20 days suppresses the p roliferative activity of splenic cells in response to stimulation with phytohemagglutinin, concanavalin A, lipopolysaccharide, pokeweed mito gen, and alloantigens. The number of antibody-producing cells in the s pleen drops on day 5 of overheating and is still low on days 10-20. Fo rty days after the start of overheating the functional activity of lym phocytes is restored. Overheating of animals does not change the colon y-forming activity of hemopoietic stem cells.