Lm. Bershtein et al., ANDROSTENEDIONE CONVERSION IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES, Bulletin of experimental biology and medicine, 117(5), 1994, pp. 516-518
The ability of human peripheral blood lymphocytes to convert the andro
genic steroid metabolite androstenedione diminishes in women over 45 y
ears old or during menopause. In patients with breast cancer in menopa
use the ability of lymphocytes to convert androstenedione is enhanced
compared with the control. The intensity of conversion in circulating
lymphocytes correlates with the blood concentration of sex steroids.