A CHRONOBIOLOGICAL STUDY OF CELL MULTIPLICATION IN ESOPHAGEAL EPITHELIUM OF MICE GIVEN LOMEFLOXACIN AT DIFFERENT TIMES OF THE DAY

Authors
ROMANOV YA IRIKOV OA FILIPPOVICH SS
Citation
Ya. Romanov et al., A CHRONOBIOLOGICAL STUDY OF CELL MULTIPLICATION IN ESOPHAGEAL EPITHELIUM OF MICE GIVEN LOMEFLOXACIN AT DIFFERENT TIMES OF THE DAY, Bulletin of experimental biology and medicine, 117(5), 1994, pp. 526-529
Citations number
15
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
5
Year of publication
1994
Pages
526 - 529
Database
ISI
SICI code
0007-4888(1994)117:5<526:ACSOCM>2.0.ZU;2-X
Abstract
The diurnal rhythmic pattern of cell division is preserved after both afternoon and night injection of lomefloxacin, but a rightward phasic shift of the diurnal rhythm is observed, the amplitude of rhythmic flu ctuations being unchanged. In both cases the mesor of the mitotic inde x virtually does not differ from that of the control, and the pool of dividing cells over 24 hours and throughout the follow-up period is ev en larger than the control values, which attests to a high adaptive po tential of the proliferative system of esophageal epithelium.