TRANSIENT PATTERNS OF CALBINDIN-D-28K EXPRESSION IN THE DEVELOPING STRIATUM OF MAN

In fetal and adult human brains, calbindin immunoreactivity (CB-ir) of neostriatal neuropil showed inhomogeneous pattern. A mosaic of CB-ir neuropil patches matching the acetylcholinesterase (AChE)-reactive pat ches and most of the encapsulated cell-dense islands was distributed i n a lighter stained background matrix. During infancy, the pattern of CB expression changed from one of CB-rich patches to one of CB-poor st riosomes and rich matrix. Furthermore, we observed a steady developmen t of population of medium-sized neurons in the striatal matrix; in add ition, a transient CB-expression was found in cells of the ganglionic eminence and presumably in a subset of striatal interneurons. (C) 1996 Elsevier Science Ireland Ltd.