Y. Ando et al., ANTIBODY-PRODUCTION AGAINST HEPATITIS-C VIRUS CORE AND NONSTRUCTURAL-3 PROTEINS IS HIGHLY SENSITIVE TO DEFICITS IN T-CELL FUNCTION, Clinical and diagnostic laboratory immunology, 4(1), 1997, pp. 104-106
The influence of suppression of CD4(+) and CD8(+) T cells on the humor
al responses to hepatitis C virus (HCV) core and nonstructural 3 prote
ins was studied. An increasing viral burden cannot substitute for the
lack of functional T cells in maintaining humoral HCV-specific respons
es.