Among 15 patients with brain metastases from colorectal cancer, the ei
ght patients treated by open surgery+whole brain irradiation (35-45 Gy
) or gamma-knife surgery had significant improvement in their neurolog
ic symptoms and were able to return to their daily life. Survival from
the time of diagnosis of brain metastases to death averaged 7.6 month
s in these radically-treated patients compared to 1.7 months in the co
nventional group (p<0.05). If performance status permits, aggressive t
reatment such as open surgery or gamma-knife surgery should be an opti
on for treatment of brain metastasis of colorectal cancer.