In the last decade, clinical management of neutropenic enteritis has b
een most controversial due to the large variability in the clinical ma
nifestations and evolution. In this work, two-case report are presente
d showing the broad spectrum of symptoms and prognosis. Intestinal per
foration, abscess, obstruction and pneumatosis are factors associated
with poor prognosis referred in the literature, and all of which indic
ate an early surgical intervention. In its absence, a close medical co
ntrol with hematological support and broad spectrum antibiotic therapy
could be indicated. In this case, surgery should be the approach for
patients with a rapidly progressive evolution or massive or continuous
intestinal bleeding, in spite of the conservative therapy.