ETOPOSIDE PHARMACOKINETICS IN A JAUNDICED INFANT WITH LETTERER-SIWE VARIANT OF LANGERHANS CELL HISTIOCYTOSIS

Authors
PLOWMAN PN JOEL SP HERMAN S
Citation
Pn. Plowman et al., ETOPOSIDE PHARMACOKINETICS IN A JAUNDICED INFANT WITH LETTERER-SIWE VARIANT OF LANGERHANS CELL HISTIOCYTOSIS, Oncology Reports, 1(6), 1994, pp. 1233-1234
Citations number
5
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
1
Issue
6
Year of publication
1994
Pages
1233 - 1234
Database
ISI
SICI code
1021-335X(1994)1:6<1233:EPIAJI>2.0.ZU;2-V
Abstract
An infant with hepatocellular jaundice due to Langerhans cell histiocy tosis was treated and responded well to intravenous etoposide. Pharmac okinetics demonstrated similar clearance and AUC data in both the jaun diced and non-jaundiced states but myelosuppression was greater when t he infant was jaundiced. Children with hepatocellular jaundice require dose reductions of etoposide, despite the similar drag pharmacokineti cs to the non-jaundiced state. The mechanisms involved are discussed.