P. Lissoni et al., A CLINICAL-STUDY OF IMMUNOTHERAPY VERSUS ENDOCRINE THERAPY VERSUS CHEMOTHERAPY IN THE TREATMENT OF ADVANCED PANCREATIC ADENOCARCINOMA, Oncology Reports, 1(6), 1994, pp. 1277-1280
The advanced carcinoma of pancreas still remains an untreatable diseas
e. Both chemotherapy and hormono-therapy seem not to prolong the survi
val time. Also immunotherapy with IL-2 has been shown to have no effic
acy. Our experimental studies suggested the possibility of enhancing t
he antitumor activity of IL-2 by the administration of immunomodulatin
g neurohormones, such as melatonin (MLT). This study was carried out t
o evaluate the efficacy of IL-2 plus MLT in advanced cancer of the pan
creas. Fifty patients, with advanced adenocarcinoma of the pancreas, w
ere randomized to receive chemotherapy consisting of 5-FU plus folates
, endocrine therapy with LHRH and somatostatin analogues, supportive c
are alone or immunotherapy with subcutaneous low-dose IL-2 plus MLT. A
partial response was obtained in 1/13 patients treated with chemother
apy and in 2/12 patients receiving immunotherapy; no tumor regression
was seen in the other groups. The percent of survival at 1 year achiev
ed in patients treated with immunotherapy was significantly higher tha
n in the other groups tested (3/12 vs 1/38; p<0.02). This preliminary
study would suggest that the immunotherapy with IL-2 plus MLT may repr
esent a new promising treatment of advanced pancreatic adenocarcinoma.