Adults with epilepsy completed self-report measures of exercise partic
ipation, barriers to exercise, stressful life experience, depression,
and general psychosocial adjustment (n = 133) as part of routine outpa
tient visits. Descriptive statistics showed lower levels of depression
among patients who exercised regularly. Structural equation analyses
confirmed the fit of a path model that included significant direct eff
ects of exercise and stressful life experience on depression. These ef
fects were independent of each other, and independent of the influence
of other predictor variables, such as seizure frequency, age, and gen
der. Stressful life experience also had a direct unique effect on seiz
ure frequency in the multivariate models. These results suggest that p
roblems with depression, which are common in adults with epilepsy, are
significantly lower among those who exercise regularly and avoid stre
ssful life change.