Em. Samy et Sm. Safwat, IN-VITRO RELEASE OF ANTIINFLAMMATORY DRUGS WITH BETA-CYCLODEXTRIN FROM HYDROPHILIC GEL BASES, STP pharma sciences, 4(6), 1994, pp. 458-465
New gel delivery systems for the local application of three non-steroi
dal anti-inflammatory drugs consist of drugs with beta-cyclodextrin in
corporated in the hydrophilic matrix of Aerosil 200, methylcellulose a
nd hydroxypropylmethylcellulose polymers. The systems were evaluated b
y infrared spectroscopy, X-ray diffractometry and differential scannin
g calorimetry techniques. The effect of beta-cyclodextrin on the relea
se of piroxicam, flubiprofen and diclofenac sodium from the hydrophili
c gel bases was investigated. Diclofenac sodium and flurbiprofen showe
d higher release rates (up to 90%) from Aerosil and hydroxypropylmethy
lcellulose respectively, and proved the superiority of the proposed fo
rmulae to the conventional one. The formulation containing diclofenac
sodium/beta-cyclodextrin showed the best release characteristics of th
e three drugs from hydroxypropylmethylcellulose gel base. The formulat
ions showed good stability after twelve weeks at 20 degrees C.