PREGELATINIZED STARCHES IN WET GRANULATION EXPERIMENTAL-DESIGN AND DATA-ANALYSIS .2. CASE OF TABLETS

In the first part of this work, the influence of two pregelatinized st arches (Primogel and Starx 1500) on galenical and rheological properti es of paracetamol granules was studied. For this study, the simple exp erience plane of Woolfall using two concentrations levels and two mixi ng times was used. The tablets obtained from these granules have shown that a low concentration of Primogel gives the best results. It is be lieved that an optimized formulation depends on certain concentrations of pregelatinized starches and on mixing time.