Pj. Smith et al., ANALYSIS OF PEDIATRIC TUMOR TYPES ASSOCIATED WITH HEMIHYPERPLASIA IN CHILDHOOD, Journal of paediatrics and child health, 30(6), 1994, pp. 515-517
In order to further explore the relationship between hemihyperplasia i
n children and the occurrence of embryonal tumours of childhood, the r
ecords at St. Jude Children's Research Hospital were examined for pati
ents who presented with a malignant tumour and hemihyperplasia. Of 27
evaluable patients, 19 had Wilms' tumour and one had massive bilateral
nephroblastomatosis. The tumours were more likely to occur on the sid
e affected by hemihyperplasia than to be found contralaterally. All bu
t five of these patients developed the tumours before the age of six.
Twenty-two of the 27 patients developed tumours associated with alleli
c loss on chromosome band 11p15, suggesting that the locus associated
with hemihyperplasia may be also located at chromosome band 11p15.