ANALYSIS OF PEDIATRIC TUMOR TYPES ASSOCIATED WITH HEMIHYPERPLASIA IN CHILDHOOD

In order to further explore the relationship between hemihyperplasia i n children and the occurrence of embryonal tumours of childhood, the r ecords at St. Jude Children's Research Hospital were examined for pati ents who presented with a malignant tumour and hemihyperplasia. Of 27 evaluable patients, 19 had Wilms' tumour and one had massive bilateral nephroblastomatosis. The tumours were more likely to occur on the sid e affected by hemihyperplasia than to be found contralaterally. All bu t five of these patients developed the tumours before the age of six. Twenty-two of the 27 patients developed tumours associated with alleli c loss on chromosome band 11p15, suggesting that the locus associated with hemihyperplasia may be also located at chromosome band 11p15.