ANGIOEDEMA FOLLOWING THE INTRAVENOUS ADMINISTRATION OF METOPROLOL

A 72-year-old woman was admitted to the hospital with ''flash'' pulmon ary edema, preceded by chest pain, requiring intubation. Her medical h istory included coronary artery disease with previous myocardial infar ctions, hypertension, and diabetes mellitus. A history of angioedema s econdary to lisinopril therapy was elicited. Current medications did n ot include angiotensin-converting enzyme inhibitors or beta-blockers. She had no previous beta-blocking drug exposure. During the first day of hospitalization (while intubated), intravenous metoprolol was given , resulting in severe angioedema. The angioedema resolved after therap y with intravenous steroids and diphenhydramine hydrochloride.