THE MOLECULAR AND CRYSTAL-STRUCTURE OF BUPRENORPHINE HYDROCHLORIDE, AMORPHINE ANALOG

Authors
KRATOCHVIL B HUSAK M BULEJ P JEGOROV A
Citation
B. Kratochvil et al., THE MOLECULAR AND CRYSTAL-STRUCTURE OF BUPRENORPHINE HYDROCHLORIDE, AMORPHINE ANALOG, Collection of Czechoslovak Chemical Communications, 59(11), 1994, pp. 2472-2480
Citations number
23
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
59
Issue
11
Year of publication
1994
Pages
2472 - 2480
Database
ISI
SICI code
0010-0765(1994)59:11<2472:TMACOB>2.0.ZU;2-K
Abstract
The structure of buprenorphine hydrochloride ethylpropyl]-6-O-methyl-6 ,14-ethano-17-normorphine hydrochloride) was solved by direct methods and refined anisotropically to the R value of 0.062 for 3 049 observed reflections. The substance crystallizes in the tetragonal space group P4(3)2(1)2, a = b = 11.513(2) Angstrom, c = 42.054(8) Angstrom, V = 5 574(2) Angstrom(3), Z = 8, D-calc = 1.201 g cm(-3), mu(MoK alpha) = 0 .17 mm(-1). The compound is the first morphine derivative with a 6,14- ethano bridge whose molecular structure has been solved.