With the increased probability of long-term survival from childhood ca
ncer, quality of life has assumed an increasingly prominent role. The
objective of the present study was to predict statistically the observ
ed variability in adaptation of long-term survivors of childhood cance
r. Perceived stress was selected for investigation as a potentially mo
difiable predictor variable, given its hypothesized role in patient fu
nctioning. Higher perceived stress statistically predicted increased p
sychological distress and lower general self-esteem after controlling
for relevant demographic and medical variables. The implications of th
ese findings suggest that stress management interventions may enhance
the quality of life of long-term survivors of childhood cancer.