STUDIES ON THE CHOLESTEROL INTERACTIONS IN AMINE-ALCOHOL AND AMINE-WATER MIXTURES

Enthalpies of solution (DELTAH(s)) of cholesterol and cholesteryl meth yl ether in the mixtures of aliphatic amines (triethylamine, di-1-buty lamine and tri-1-butylamine) with water, methanol and butan-1-ol have been determined. Using the 'pure base' method, enthalpies of the chole sterol-amine association (DELTAH(f)) in the amine-water and amine-alco hol mixtures have been calculated. The changes of DELTAH(s) and DELTAH (f) values caused by the addition to amine the hydroxyl compounds (R'O H) where discussed. The possibility of formation of amine-R'OH-cholest erol associates involving the hydroxyl group of co-solvent has been su ggested in the case of tri-1-butylamine.