Adenoviruses are well documented as opportunistic pathogens in patient
s with immunocompromising conditions, including human immunodeficiency
virus (HIV) infection. We recently diagnosed adenovirus infection of
the parotid gland in two patients with AIDS. Viral cultures and electr
on microscopic examinations of parotid tissue were positive in both ca
ses. Adenovirus infection should be considered in the differential dia
gnosis of parotid swelling in HIV-infected patients.