PLASMA-LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA IN PATIENTS WITH MEDITERRANEAN SPOTTED-FEVER - CLINICAL AND ANALYTICAL CORRELATIONS

Authors
ORISTRELL J AMENGUAL MJ FONTCREUS B CASANOVAS A SEGURAPORTA F
Citation
J. Oristrell et al., PLASMA-LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA IN PATIENTS WITH MEDITERRANEAN SPOTTED-FEVER - CLINICAL AND ANALYTICAL CORRELATIONS, Clinical infectious diseases, 19(6), 1994, pp. 1141-1143
Citations number
15
Categorie Soggetti
Microbiology,Immunology,"Infectious Diseases
Journal title
Clinical infectious diseases → ACNP
ISSN journal
10584838
Volume
19
Issue
6
Year of publication
1994
Pages
1141 - 1143
Database
ISI
SICI code
1058-4838(1994)19:6<1141:POTIPW>2.0.ZU;2-J
Abstract
Twenty consecutive patients with serologically confirmed Mediterranean spotted fever were analyzed for determination of plasma levels of tum or necrosis factor alpha (TNF-alpha) by means of an ELISA. Increased l evels of TNF-alpha in plasma were found during the acute phase of the disease (52.3 +/- 49.8 pg/mL) compared to levels in the convalescent p hase (9.0 +/- 9.3 pg/mL; P <.001) or in healthy controls (6.5 +/- 3.2 pg/mL; P <.001). Plasma TNF-alpha levels were significantly higher in patients with severe Mediterranean spotted fever. Levels of TNF-alpha correlated significantly with serum levels of C-reactive protein and t riglycerides and inversely with serum levels of sodium.