Streptomycin is' an aminoglycoside antibiotic that is indicated for th
e treatment of tuberculous and nontuberculous infections. Intramuscula
r injection is the recommended route of administration. There are few
reports on intravenous administration of streptomycin. We describe the
use of intravenous streptomycin to treat endocarditis due to a strain
of Enterococcus faecalis with high-level resistance to gentamicin. Ph
ysicians should consider the intravenous route as an alternate method
of administering streptomycin.