L. Pilch et al., ASSESSMENT OF CARTILAGE VOLUME IN THE FEMOROTIBIAL JOINT WITH MAGNETIC-RESONANCE-IMAGING AND 3D COMPUTER RECONSTRUCTION, Journal of rheumatology, 21(12), 1994, pp. 2307-2319
Objective. Our goal was the development of an accurate and objective t
echnique to depict and quantitate articular cartilage using magnetic r
esonance imaging (MRT) and 3D data processing. Methods. A method of 3D
image analysis has been developed that provides a noninvasive techniq
ue of measuring cartilage volume from standard diagnostic MR images. R
esults. Using a computer workstation, cartilage from Fast Field Echo (
FFE) MR images was reconstructed into 3 dimensions (3D). The accuracy
and reproducibility of both thickness and volume measurements obtained
from the existing computer software was tested using calibration test
objects. We describe the sources of error we encountered when attempt
ing to quantitate cartilage using the existing computer software, the
methods developed to reduce these errors, and a preliminary cartilage
volume study using healthy human volunteers. Conclusion. We have ident
ified errors involved in attempting cartilage volume estimations using
the existing 3D computer software and have developed a data processin
g technique that minimizes these errors. With these objective data pro
cessing techniques we have improved the reproducibility of the techniq
ue to +/- 10-15% error. This modified technique provides a promising n
ew method for viewing and quantifying cartilage volume from standard d
iagnostic