INFLUENCE OF GENERAL-ANESTHESIA ON ACUTE EXPERIMENTAL POISONING OF CATS WITH THE ORGANOPHOSPHORUS PESTICIDE ANTHIO

It is shown that general anesthesia strongly influences the resistance of animals to poisoning with organophosphorus compounds (OPC) such as Anthio, weakens compensatory/adaptive responses, and possibly acts sy nergistically with OPC in impairing tissue respiration. One to three d ays after peroral administration of Anthio, reduced oxygen tension in arterial blood and increased heart and respiratory rates were recorded in cats, although the arterial blood pressure tended to drop markedly . Anthio poisoning led to profound changes in the autonomic regulation of functions, which was manifested in sharply decreased parasympathet ic influences. The function of the brain's GABA-ergic system did not c hange appreciably.