THE UPTAKE OF 3-DEOXY-3-IODINE-GLUCOSE BY NORMAL AND TUMOR-CELLS IN-VITRO

Authors
KHARCHENKO VP BOZHENKO VK KHMELEVSKII EV SHISHKIN AM ZAKHAROV AG
Citation
Vp. Kharchenko et al., THE UPTAKE OF 3-DEOXY-3-IODINE-GLUCOSE BY NORMAL AND TUMOR-CELLS IN-VITRO, Bulletin of experimental biology and medicine, 117(6), 1994, pp. 659-661
Citations number
7
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Bulletin of experimental biology and medicine → ACNP
ISSN journal
00074888
Volume
117
Issue
6
Year of publication
1994
Pages
659 - 661
Database
ISI
SICI code
0007-4888(1994)117:6<659:TUO3BN>2.0.ZU;2-B
Abstract
It is found that 3-deoxy-3-iodine-glucose (3D-I-glucose) enters both e rythrocytes and tumor cells at a rate close to that of glucose entry. For tumor cells the total uptake of the preparation was 6-fold higher than for erythrocytes (1500 and 250 mu M/mln. cells, respectively). Ph osphorylated products of 3D-I-glucose were not detected; however, the total amount of preparation in the probes dropped during incubation, i ndicating that it is metabolized by the cells.