Background. - Assessing pain in premature babies is difficult because
of their limited capacities to communicate. The aim of this study was
to recognize manifestations of acute and chronic pain or, on the contr
ary, of well-being state, and to validate a ''pain scale'' for prematu
re babies. Population and methods. - Premature babies less than 28 day
s of age (most of them less than 32 weeks of gestational age) were car
efully observed during their stay in a neonatal intensive care unit by
nurses, physicians, physiotherapists and a psychiatrist. All signs an
d symptoms were collected during situations a priori painful and compa
red to the behavior of the well-being states. Photographs and videofil
ms were also analysed. Results. - Five items, scored from 0 to 4, were
established, based on facial activity, movements and posture of the b
ody, quality of sleep, relationship with the examiner, and efficacy of
measures of comforting. These items permitted to describe four patter
ns corresponding to 1: well-being status, 2: acute pain, 3 and 4: dura
ble pain or discomfort either through clinical picture of irritability
or motionlessness. A strict concordance of scores for the five items
between the different examiners was found in 80% of the 50 babies stud
ied. The sensibility of the scale (studied in 12 babies) appeared accu
rate (77% of variation of the scores during hospitalization). Conclusi
ons. - An objective assessment of pain and discomfort in premature bab
ies can be made using a ''pain scale'' useful for care and therapeutic
decisions.