REGULATION OF HEME-REGULATED EIF-2-ALPHA KINASE AND ITS EXPRESSION INERYTHROID-CELLS

Authors
CHEN JJ CROSBY JS LONDON IM
Citation
Jj. Chen et al., REGULATION OF HEME-REGULATED EIF-2-ALPHA KINASE AND ITS EXPRESSION INERYTHROID-CELLS, Biochimie, 76(8), 1994, pp. 761-769
Citations number
73
Categorie Soggetti
Biology
Journal title
Biochimie → ACNP
ISSN journal
03009084
Volume
76
Issue
8
Year of publication
1994
Pages
761 - 769
Database
ISI
SICI code
0300-9084(1994)76:8<761:ROHEKA>2.0.ZU;2-G
Abstract
In this article we focus first on the molecular mechanisms controlling the activity of the heme-regulated translational inhibitor, HRI, in e rythroid cells. Then we discuss the tissue-specific expression of HRI. The experimental evidence obtained to date indicates that the major p hysiological role of HRI is in adjusting the synthesis of globin to th e availability of heme.