MOLECULAR-CLONING OF CDNA-ENCODING THE 110-KDA AND 21-KDA REGULATORY SUBUNITS OF SMOOTH-MUSCLE PROTEIN PHOSPHATASE-1M

Authors
CHEN YH CHEN MX ALESSI DR CAMPBELL DG SHANAHAN C COHEN P COHEN PTW
Citation
Yh. Chen et al., MOLECULAR-CLONING OF CDNA-ENCODING THE 110-KDA AND 21-KDA REGULATORY SUBUNITS OF SMOOTH-MUSCLE PROTEIN PHOSPHATASE-1M, FEBS letters, 356(1), 1994, pp. 51-55
Citations number
23
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
356
Issue
1
Year of publication
1994
Pages
51 - 55
Database
ISI
SICI code
0014-5793(1994)356:1<51:MOCT1A>2.0.ZU;2-5
Abstract
The structures of the M(110) and M(21) regulatory subunits of protein phosphatase-1M, the major enzyme which dephosphorylates myosin in smoo th muscle, have been deduced from cloned cDNAs. The N-terminus of the M(110) subunit from rat aorta contains seven ankyrin repeats, while th e C-terminus of the M(21) subunit from chicken gizzard contains a leuc ine zipper motif. The M(110) subunit is expressed in two different for ms which differ in their C-terminal sequences. One of these is highly homologous to the whole of the M(21) subunit.