NUCLEOSIDE AND NUCLEOBASE ANALOG MUTAGENS

Authors
NEGISHI K BESSHO T HAYATSU H
Citation
K. Negishi et al., NUCLEOSIDE AND NUCLEOBASE ANALOG MUTAGENS, Mutation research. Reviews in genetic toxicology, 318(3), 1994, pp. 227-238
Citations number
104
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
Mutation research. Reviews in genetic toxicology → ACNP
ISSN journal
01651110
Volume
318
Issue
3
Year of publication
1994
Pages
227 - 238
Database
ISI
SICI code
0165-1110(1994)318:3<227:NANAM>2.0.ZU;2-G
Abstract
Compounds with structures close to those of normal nucleosides or nucl eobases may be incorporated into cells and then become constituents of their DNA. Proliferation of such cells could yield mutants. In this a rticle, the current status of studies on such nucleoside and nucleobas e analogs is described. Base mispairing mechanisms for these analogs a re discussed in light of recent biochemical and biophysical findings.