ACTION OF NITROGENATED AND SULFONYLATED INOSITOL DERIVATIVES UPON THEPROLIFERATION IN-VITRO OF NORMAL MOUSE CELLS AND TUMOR MOUSE CELLS

Despite the major advances of cancer chemotherapy during the past 40 y ears, host toxicities and drug resistance justify the need to continue the search for new antineoplastic agents. In the present work, we hav e studied the effect of six synthetic drugs on the in vitro growth of two murine mammary adenocarcinomas (M3 and MM3), as well as on normal embryonic cells. AI, MIC and MPI are purines coupled to a sulfonylated inositol, while DIC and DEI have nitrogen mustard as substituent. Met hylsulfonylmucoinositol was the common substituent. Our results indica ted that only drugs substituted with nitrogen mustards had an antiprol iferative effect. DEI was more effective on tumor cells than on normal cells.