INTERPRETIVE CRITERIA AND QUALITY-CONTROL PARAMETERS FOR TESTING BACTERIAL SUSCEPTIBILITY TO THE FLUOROQUINOLONE PD131628

For testing bacterial susceptibility to PD131628, a 5-mu g disk and th e following tentative interpretive criteria may be used: greater than or equal to 19 mm for susceptible (MIC, less than or equal to 1.0 mu g /ml), 16 to 18 mm for intermediate (MIC, 2.0 mu g/ml), and less than o r equal to 15 mm for resistant (MIC, greater than or equal to 4.0 mu g /ml). For standard quality control strains, the following limits are p roposed: for Escherichia coli ATCC 25922, zones of 31 to 41 mm or a MI C of 0.002 to 0.016 mu g/ml; for Pseudomonas aeruginosa ATCC 27853, zo nes of 26 to 34 mm or a MIC of 0.12 to 0.5 mu g/ml; for Staphylococcus aureus ATCC 25923, zones of 27 to 33 mm; for Staphylococcus aureus AT CC 29213, a MIC of 0.03 to 0.12 mu g/ml; and for Enterococcus faecalis ATCC 29212, a MIC of 0.12 to 0.5 mu g/ml.