BLOCKADE OF FEEDING INHIBITION BY NEUROMEDIN-B USING A SELECTIVE RECEPTOR ANTAGONIST

The ability of a selective neuromedin B receptor antagonist, D-Nal-cyc lo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppressio n of food intake produced by the mammalian bombesin-like peptides neur omedin B and neuromedin C was examined. BIM-23127 completely blocked s uppression of intake produced by neuromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrat e the utility of this group of antagonists for in vivo experiments.