Despite improvements in surgical techniques, the results of open fetal
surgery to correct congenital diaphragmatic hernia have been disappoi
nting. Hysterotomy induces preterm labour and, where there is a large
volume of liver in the fetal chest, reduction of the liver into the ab
domen induces immediate fetal death. Less invasive techniques, using b
oth open surgery and fetoscopy, are being developed in the hope of red
ucing fetal demise. These techniques include blocking the trachea, the
creation of an artificial gastroschisis and induction of graft tolera
nce for postnatal lung transplantation.