Background The successful development of cataract operation and IOL im
plantation in the last decade has resulted in progressive shortening o
f the incision length as well as in developing safer and simpler anest
hetic techniques. The purpose of the present study was to evaluate whe
ther cataract surgery with scleral incision is possible using only top
ical sponge anesthesia with oxybuprocaine 0.4%. This method was compar
ed with retrobulbar injection. Methods 150 patients (3 groups each con
sisting 50 eyes) underwent phaco with scleral incision. 1st group: oxy
buprocaine sponge anesthesia. 2nd group: oxybuprocaine sponge anesthes
ia combined with mild systemic analgesia (tramadol p.o.). 3rd group: r
etrobulbar injection (prilocaine/etidocaine mixture). All patients rec
eived medazolam premedication (Dormicum(R), 3/10 of 1 cc). Pain and di
scomfort during and after operation were investigated and statisticall
y analyzed. Results Neither in group 1, 2 or 3 an additional subconjun
ctival injection was necessary. Pain or discomfort during operation wa
s felt in 14 percent of the patients anesthetized with the oxybuprocai
ne sponge but only in 6 percent of the patients additionally premedica
ted with tramadol (2nd group). Also 6 percent of the patients after re
trobulbar in jection felt pain during operation. Postoperatively no si
gnificant differences between group 1 and 2 were obtained: 6 per cent
felt pain, 30 percent had a short term foreign body sensation. After r
etrobulbar injection (group 3) only 10 percent felt postoperative pain
or discomfort. Conclusions Topically applied oxybuprocaine provides s
ufficient anesthesia during cataract surgery with scleral incision. A
combination with mild systemic analgesia (tramadol) helps to minimize
pain and discomfort. Retrobulbur injection yielded only in the postope
rative period significantly better analgesia. In the operating room fu
ll cooperation of the patient is required. Therefore we recommend not
to use sponge anesthesia in cases when communication between surgeon a
nd patient is insufficient.