N. Hebert et al., SYNTHESIS OF N-SUBSTITUTED HYDROXYPROLINOL PHOSPHORAMIDITES FOR THE PREPARATION OF COMBINATORIAL LIBRARIES, Tetrahedron letters, 35(51), 1994, pp. 9509-9512
A series of N-substituted DMT-hydroxymethylpyrrolidinol phosphoramidit
es has been prepared from trans-4-hydroxyproline. These can be coupled
in high yield and purity using automated synthesis techniques, allowi
ng a wide range of functionalities to be introduced into phosphodieste
r oligomers.