SYNTHESIS AND ANTIRETROVIRAL EVALUATION OF 3-ALKYL 2-PIPERAZINONE NUCLEOSIDE ANALOGS

Authors
BENJAHAD A BENHADDOU R GRANET R KAOUADJI M KRAUSZ P PIEKARSKI S THOMASSON F BOSGIRAUD C DELEBASSEE S
Citation
A. Benjahad et al., SYNTHESIS AND ANTIRETROVIRAL EVALUATION OF 3-ALKYL 2-PIPERAZINONE NUCLEOSIDE ANALOGS, Tetrahedron letters, 35(51), 1994, pp. 9545-9548
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
51
Year of publication
1994
Pages
9545 - 9548
Database
ISI
SICI code
0040-4039(1994)35:51<9545:SAAEO3>2.0.ZU;2-P
Abstract
Glycosylation of 3-alkyl N-4-(3-hydroxypropyl) 2-piperazinones by prot ected 1-O-acetyl ribofuranoses produces nucleoside analogs in which th e base is separated from the sugar by a hydrocarbon spacer arm. The pr eliminary in vitro test results against retroviruses seem promising fo r compounds bearing a long alkyl chain.