EFFECT OF LIVER-DAMAGE ON THE PHARMACOKINETICS OF DEXAMETHASONE

Authors
KUTEMEYER S SCHURMEYER TH VONZURMUHLEN A
Citation
S. Kutemeyer et al., EFFECT OF LIVER-DAMAGE ON THE PHARMACOKINETICS OF DEXAMETHASONE, European journal of endocrinology, 131(6), 1994, pp. 594-597
Citations number
33
Categorie Soggetti
Endocrynology & Metabolism
Journal title
European journal of endocrinology → ACNP
ISSN journal
08044643
Volume
131
Issue
6
Year of publication
1994
Pages
594 - 597
Database
ISI
SICI code
0804-4643(1994)131:6<594:EOLOTP>2.0.ZU;2-B
Abstract
By measuring the pharmacokinetics of dexamethasone in 48 patients with various degrees of disturbances in liver function, we could demonstra te a decrease in the metabolic clearance of this steroid by 53% if the activity of the plasma cholinesterase was lowered to less than 2 kU/l . Results suggest that the dosage of dexamethasone given for diagnosti c or therapeutic purpose needs to be adjusted in such patients.