GASTRODUODENAL SENSORY MECHANISMS AND CCK IN INHIBITION OF GASTRIC-EMPTYING IN RESPONSE TO A MEAL

The ability of nutrients in the intestinal lumen to exert feedback con trol over the proximal gastrointestinal tract function is well recogni zed, yet the control mechanisms are poorly defined. There is evidence that extrinsic sensory pathways from the intestine are required to ini tiate this regulatory process. Furthermore, CCK appears to be involved in the gastric response to several intestinal stimuli, such as fat, c arbohydrate and protein. Our hypothesis is that nutrients release CCK from the intestine, which then stimulates intestinal mucosal afferents to signal reflex changes in gastric motor function and thus inhibit g astric emptying.