ADRENOMEDULLARY FUNCTION IN DEPRESSED-PATIENTS

In this paper from the Collaborative Depression Study (CDS)-Biological , a set of data analyses are presented which indicate that depressed s tates and perhaps depressed mood are associated with a greater activat ion of the adrenomedullary system than the sympathetic nervous system [as measured by norepinephrine (NE) and normetanephrine excretion]. Fo r the most part this finding of predominant activation of the adrenome dullary system is seen in unipolar and not bipolar patients.