NORPLANT-ASSOCIATED MAJOR DEPRESSION AND PANIC DISORDER

Background: Norplant is a long-acting subdermal implant system that is widely used for contraception. The implant releases a continuous dose of levonorgestrel, a synthetic progestin. Although oral contraceptive s are associated with depression and panic disorder, no cases have bee n reported of psychiatric disorders secondary to the use of Norplant. Method: Two women, aged 18 and 29 years, are described who developed m ajor depression and panic disorder while using the Norplant system. Re sults: These women who had no prior psychiatric history developed majo r depression and panic disorder 1 to 2 months after insertion of Norpl ant system capsules. The symptoms worsened over the course of a year. Following removal of Norplant, the symptoms of depression and anxiety resolved within 1 month. Conclusion: The progesterone content of oral contraceptives has been linked to major depression and panic disorder. Since Norplant is a progestin-only preparation, it is likely that som e women will develop these disorders. These cases illustrate the impor tance of careful follow-up for adolescents and adults who select Norpl ant for contraception. Patients should be informed about the possible occurrence of psychiatric disorders. When evaluating new onset of depr ession and panic disorder in adolescent and adult women, it is importa nt to inquire about Norplant insertion.