Sexually transmitted diseases (STDs) can substantially increase the mo
rbidity and mortality of exposed adults and children. Despite the adve
nt of new antibiotics and focus on behavioral interventions such as co
ndom use, attempts to limit the spread of STDs have been largely unsuc
cessful. Vaccines have received increasing attention as a potential st
rategy for STD control. This article focuses on the current status of
vaccine research for five classic STDs: gonorrhea, genital herpes, syp
hilis, chancroid and chlamydia.