Background. This study evaluated the effect of a radically redesigned
curriculum at Harvard Medical School on preclinical students' knowledg
e, skills, personal characteristics, approaches to learning, and educa
tional experiences. Method. Multiple measures were used to collect dat
a from 121 students from the entering classes of 1989 and 1990 who had
been randomly assigned to the New Pathway or traditional curricula; a
ll had applied to be in the new curriculum. Results. The New Pathway s
tudents reported that they learned in a more reflective manner and mem
orized less than their control counterparts in the traditional curricu
lum during the preclinical years. The New Pathway group preferred acti
ve learning and demonstrated greater psychosocial knowledge, better re
lational skills, and more humanistic attitudes. They felt more challen
ged, had closer relationships with faculty, and were somewhat more anx
ious than those in the traditional program. There was no difference in
problem-solving skills or biomedical knowledge base. Conclusion. Stud
ents in the new curriculum learned differently, acquired distinctive k
nowledge, skills, and attitudes, and underwent a more satisfying and c
hallenging preclinical medical school experience without loss of biome
dical competence. These findings should encourage other schools to con
sider such a curriculum.