PHARMACODYNAMICS AND PHARMACOKINETICS OF VELITEN(R) (RUTINE, ALPHA-TOCOPHEROL AND ASCORBIC-ACID) IN PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY

The aim of this study was to evaluate the pharmacodynamics and pharmac okinetics of a single oral dose of Veliten(R) in 12 patients affected by chronic venous insufficiency. In particular, the pharmacokinetics o f two components of Veliten(R), namely rutine and alpha-tocopherol, we re considered, while with respect to pharmacodynamics, studies were ma de of venous function, haemocoagulative and fibrinolytic balance, and haemorheological parameters. Correlation between such changes and plas ma drug levels was also evaluated. We found a significant increase of venous tone, venous capacity and venous distension after drug intake, as well as a significant activation of fibrinolysis (globally evaluate d with euglobulin lysis time), related to a slight increase of plasmin ogen tissue activator. These changes appeared concomitantly with maxim al plasma levels of rutine. We did not find any modifications of coagu lative and haemorheological parameters.