THE CLINICAL PROGNOSTIC FACTORS IN BREAST -CARCINOMA

We studied the clinical factors of metastatic risk of breast cancer in 5609 consecutive cases of unilateral invasive breast cancer, wholly t reated and followed at Rene-Huguenin Center from 1962 to 1988, and wit hout any other cancer (even a controlateral breast cancer). All these patients were protocolary treated; these protocols, especially medical treatments (chimio and hormonotherapy), being modified along with yea rs. At 20 years, the global metastasis free survival was 56%. Clinical size, existence of inflammatory signs, UICC clinical stage, clinical nodal status were highly significant in the Cox multivariate analysis (P < 0.000001). Age CP < 0.0008) and adherence to skin or underlying p arietal (P < 0.007) were also but less significant. On the other hand, location of the tumor, time between first signs and diagnosis were no t predictive. The women under 35 years had more metastatic locations d uring their evolution (P < 0.05) and maybe more visceral metastasis (N S).