DO SMOKING AND DIABETES CHANGE THE HEMOSTATIC PARAMETERS - A STUDY INTHE CHINESE PEOPLE

Plasma plasminogen activator inhibitor-1 (PAI) antigen, fibrinogen, an tithrombin III (ATIII), protein C, B-thromboglobulin (BTG), platelet c ount, fibrinogen degradation product (FDP) D-dimer, factors VII and XI I, as well as cholesterol, triglyceride (TG) and glucose were determin ed in 163 subjects. First we compared the difference of these paramete rs between 50 diabetics (Group D, mean age 64.9 years and 50 age-match ed healthy controls (Group C, mean age 63.1 years), Nineteen of the di abetics and 19 of the healthy controls were smokers. Plasma glucose, c holesterol, TG and protein C were significantly higher in Group D than in Group C (p = 0.0010, 0.0308, 0.0083 and 0.0068, respectively), whe reas ATIII and factor XII were significantly lower in Group D (p = 0,0 213 and 0.0061) Secondly, we divided 113 healthy controls (Group C inc luding Group C plus 63 subjects at various ages) in smokers (mean age 56.7 years) and non-smokers (mean age 40.0 years) and compared the dif ference between them. Fibrinogen and glucose were higher in the smoker s than in the non-smokers (p = 0.0139 and 0.0402, respectively) Other parameters were not different. In conclusion, our study did not find a ny important hypercoagulation state in the diabetics. Smoking can only increase fibrinogen and glucose without the change of other hemostati c parameters.