The fabrication of microsystems in which chemical measurements play a
role make the on-chip combination of chemical sensors and signal proce
ssing circuitry highly desirable. Chemical sensors use sensitive layer
s which are not a part of MOS devices and in this sense, the determina
tion of the best sensors and technological processes to achieve good i
ntegrated smart sensors is very important. In this paper a study of co
mpatibility of ISFET chemical sensors and CMOS circuitry is presented
for application to biomedical microsystems.