SORPTION OF UNCONJUGATED BILIRUBIN BY MEANS OF NOVEL IMMOBILIZED BETA-CYCLODEXTRIN POLYMERS

Three kinds of novel beta-cyclodextrin (beta-CyD) polymers were synthe sized by immobilization of beta-CyD onto the crosslinked polystyrene s upports with different functional groups such as -CH2Cl, -SO2Cl and -C H2-CH-O-CH2. As biomedical absornents, they were tested for their remo val capacity of unconjugated bilirubin (BR). The results indicate that the adsorption capacity for BR is due to the inclusion interaction be tween beta-CyD and BR. Many factors such as the adsorption time, the p H value of the adsorption medium, the concentrations of BR and albumin , the amount of beta-CyD immobilized on the supports and the degree of crosslinking may affect the adsorption capacity. The adsorption mecha nism was also studied.